Research You Should Know About – Health Care Professionals

Cholesterol crystals starts Atherosclerosis – Click to access the journal article or abstract

Dietary Cholesterol and Inflammation – 2013 Review Article

Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.  Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

PLoS One. 2010 Jul 23;5(7):e11765. doi: 10.1371/journal.pone.0011765Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.  

Am J Cardiol. 2009 Apr 1;103(7):959-68. doi: 10.1016/j.amjcard.2008.12.019. Epub 2009 Feb 7. Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes. Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, MI, USA.

Nikolai N. Anichkov (1885–1964) first demonstrated the role of cholesterol in the development of atherosclerosis. His classic experiments in 1913 paved the way to our current understanding of the role of cholesterol in cardiovascular disease. Anichkov’s research is often cited among the greatest discoveries of the 20th century; however, little is known about Anichkov and his team. Herein, we give a detailed historical account of Anichkov’s work, his personality, his research team, and their pioneering effort. Tex Heart Inst J. 2006; 33(4): 417–423.;Nikolai N. Anichkov and His Theory of Atherosclerosis

Pan A, Sun Q, Bernstein AM, Manson JE, Willett WC, Hu FB. Changes in Red Meat Consumption and Subsequent Risk of Type 2 Diabetes Mellitus: Three Cohorts of US Men and Women. JAMA Intern Med. 2013;():1-8. doi:10.1001/jamainternmed.2013.6633.

Yaffe K, et al “Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus” JAMA Intern Med 2013; DOI: 10.1001/jamainternmed.2013.6176.

Lipska KJ, Montori VM “Glucose control in older adults with diabetes mellitus — More harm than good? JAMA Intern Med 2013; DOI: 10.1001/jamainternmed.2013.6189.

Fish Consumption Multiplies Prostate Cancer Risk
Population studies have consistently showed that people such as the Japanese who eat fish have overall better health with less heart disease and cancer than people who eat the standard American diet. It was believed that the beneficial factor was the fish, forgetting that the Japanese also eat more fruits and vegetables, much less meat and almost no dairy products. Researchers tracked the diets and prostate cancer diagnoses of 18,115 Japanese men. They found that fish intake was the only dietary factor significantly associated with increased risk of developing prostate cancer. Men who ate fish products 4 or more times per week had a 54 % higher risk of developing prostate cancer compared to men who ate fish products less than than twice per week.

– Allen NE, Sauvaget C, Roddam AW, et al. A prospective study of diet and prostate cancer in Japanese men. Cancer Causes Control. 2004;15:911-20.